If you have a supported email program, you can configure your email program automatically simply by adding an email account in the Account Preferences Window. Spamfire has built-in support for the most popular email programs. Spamfire will automatically make needed changes in your email program. Spamfire can also reverse any changes it makes automatically.
If you have an unsupported email program, you can configure it manually. How you configure your email program depends on whether you want to use Proxy or Helper mode in Spamfire.